Venous stasis and thrombin generation

Thrombin generation and venous thromboembolism.

Venous thromboembolism is a chronic and potential fatal disease. Determination of recurrence risk is time-consuming and costly, and sometimes not feasible: many patients carry more than one risk factor, the relevance of some factors with regard to risk of recurrence is unknown, and existence of thus far unknown risk factors must be considered. A laboratory assay that measures multifactorial thr...

Thrombin generation profiles in deep venous thrombosis.

BACKGROUND Reliable markers and methods to predict risk for thrombosis are essential to clinical management. OBJECTIVE Using an integrated approach that defines an individual's comprehensive coagulation phenotype might prove valuable in identifying individuals at risk for experiencing a thrombotic event. METHODS Using a numerical simulation model, we generated tissue factor (TF) initiated t...

Venous stasis and activation of coagulation

AORN guideline for prevention of venous stasis.

© AORN, Inc, 2007 INTRODUCTION Deep venous thrombosis (DVT) and pulmonary embolus (PE) are major risk factors for patients undergoing surgical or other invasive procedures, and thromboprophylaxis should be considered for all these patients. Prevention of venous thromboembolism (VTE), a combination of DVT and PE, is more effective than treatment and is an important aspect of patient care before,...

Platelets and thrombin generation.

This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin. Studies have demonstrated that on activation, the amount of one specific lipid, phos...